Start doing your own research about opportunities on campus. Don’t be afraid to talk to people. Most people in this field would love to talk about their work
Sophia Caron
Human Biology
Research Topic: Modeling Thyroid Hormone Dynamics and Chemical Disruption: Integrating High-Throughput Methods with Primary Human Hepatocytes
Graduation Year: 2024
Undergraduate Research in the Neighborhoods
At the Johnson Lab, Sophia’s goal, along with faculty, is to develop in vitro, human cell-based assays sensitive to thyroid hormone (TH) disruption caused by a diverse class of chemicals known as Polychlorinated dioxins and dibenzofurans (PCDD/F) and polychlorinated biphenyls (PCBs). Currently, Sophia is working with primary liver cells (PHH) and has demonstrated the inducibility of Phase 1 Cytochrome P450 enzymes, which is important for monitoring changes in TH hepatic clearance. These findings support the requirements of the PHH spheroid model to recapitulate PDCC/F-induced changes in hepatic TH action and kinetics.
Learn more about this and other research in the Neighborhood Engagement Centers.
.png)
